MutationΦ-values experimentalΦ-values theoreticalCorrelation
U1A
I11V0.10.690.88
I13A0.350.66
L16A0.20.68
L25A0.350.80
L29A0.40.82
F33A0.40.75
I39A0.40.92
V44A0.60.88
L68A00.38
I83V00.41
 
SH3 domain of α-spectrin
L8S0.160.140.77
A11G00.15
D14S0.160.25
V23A0.320.44
T24A0.290.30
D29A0.220.21
K43A0.260.72
V44A0.480.58
N47G0.630.56
F52A0.580.63
V53A0.610.51
A55G0.530.59
V58A0.160.23
 
Sso7d
V4A0.010.260.68
E12A0.240.21
R25A0.650.81
I30A0.440.80
F32A0.430.62
D35A0.30.60
T41A0.220.39
R43A0.210.27
A45G0.590.55
V46A0.090.46
A51G0.220.60
L55A0.210.70
L56A0.270.72
Q57G0.540.76
L59A0.60.78
 
B1 domain of protein G
I6A0.380.590.83
L7A0.320.35
T11A0.020.32
T16A00.24
A20G0.020.29
D22A0.230.37
A26G0.310.46
V29A0.260.53
K31G0.230.64
Q32G0.550.66
Y33A0.20.35
A34G0.210.46
N35G0.190.42
V39A0.160.27
D46A0.960.80
D47A0.670.78
T49A0.840.82
T51A0.440.76
T53A0.270.70
V54A0.160.56
 
TNfn3 domain of tenascin
L2A0.040.080.63
P5A0.040.13
I8A0.10.13
V10A0.230.09
A18G0.140.14
I20A0.390.28
I29A0.130.43
I32A0.190.49
L34A0.350.61
Y36A0.530.60
I48A0.670.65
L50A0.420.58
Y57A0.380.46
Y57G0.250.46
I59V0.640.32
I59A0.60.33
L62A0.330.28
P64A0.470.19
T66S0.60.39
T66A0.250.39
Y68F0.420.43
V70A0.540.40
L72A0.290.44
S81A0.030.21
A84G0.210.14
E86A0.080.11
E86G0.090.14
F88A0.110.16
T90S0.160.13
T90A0.110.15
 
CheY
A36G0.750.910.61
D38G0.60.88
A42G0.680.89
I55V0.30.76
D64A0.110.85
I72V0.050.81
A98G0.030.32
T112G0.120.24
I123V0.120.08
 
barnase
I4V00.190.68
N5A0.10.17
T6A0.20.44
T6G0.20.44
V10A0.40.38
L14A0.60.46
T16S0.80.46
T26A00.17
T26G00.17
V36A00.08
I55V0.50.55
N58A10.53
I76V00.49
N77A00.49
Y78F00.27
N84A0.10.46
I88V0.80.59
S91A0.90.85
S92A10.75
I96V0.40.65
I109V0.20.71
 
suc1
R3A0.380.090.49
L5A0.220.12
S8G0.540.12
E9A0.20.11
E11G0.260.17
L13A0.30.25
I20V0.190.43
S23G0.070.53
R25A0.20.59
A27G0.260.56
Y31A0.710.77
E32A0.630.70
R34A0.480.77
H35A0.070.69
V36A0.680.70
L38A0.420.62
K44G0.010.47
P47A0.190.22
D49A0.190.25
L58A0.190.56
R59A0.210.51
I60V0.640.75
E65A0.020.53
R67G0.430.85
L69A0.30.62
E78G0.570.89
Y80G0.510.90
E81A0.190.68
V82G0.680.68
P85A0.460.71
P85G0.810.71
H88A0.770.67
L90A0.460.79
K93A0.770.88
R94A0.570.74
K96A0.670.61
 
S6
V6A0.520.550.51
I8A0.460.52
L19A0.240.48
I26A0.40.61
L30A0.340.69
V37A0.240.74
V65A0.380.76
L75A0.40.56
V88A0.140.28
V90A0.140.31
 
CI2
K2M0.030.220.63
T3A0.130.20
T3G0.050.20
P6A0.070.43
E7A0.40.53
L8A0.150.67
S12G0.290.78
S12A0.430.80
K17A0.280.75
K17G0.380.75
K18G0.70.82
I20V0.40.71
L21A0.250.67
L21G0.350.68
Q22G0.120.77
K24G0.10.56
P25A0.20.67
E26A0.420.63
I29V0.170.61
I29A0.250.61
I30A0.310.59
I30G0.260.59
L32A0.190.48
V34G0.160.36
V38A0.120.28
T39A0.190.25
E41A0.320.33
Y42G0.070.23
R43A0.090.52
V47A0.210.58
L49A0.530.67
F50A0.30.53
V51A0.250.53
D52A0.120.53
N56A0.090.54
I57A0.080.61
A58G0.110.52
V60G0.040.45
P61A0.020.43
V63A0.030.17
V63G0.030.17
 
FKBP12
V2A0.390.090.29
V4A0.270.09
I7V0.090.19
T21A0.40.82
T21S0.470.83
V23A0.520.83
V24A0.380.86
T27A0.280.90
T27S0.390.89
F36A0.150.76
L50A0.390.55
V55A0.080.70
I56A0.190.48
R57A0.330.51
R57G0.140.51
E60A0.140.71
E60G0.130.71
E61A0.030.51
E61G0.20.49
V63A0.510.60
T75A0.240.49
I76V0.430.54
I76A0.340.45
I91V0.330.36
I91A0.040.31
L97A0.230.58
V98A0.270.73
V101A0.570.77
L106A0.350.51
 
Im7
L3A0.520.45-0.18
I7V0.560.34
F15A0.300.52
V16A0.720.51
L18A0.520.74
L19A0.340.53
I22V0.280.76
V27A0.560.36
V33A0.000.68
L34A0.490.63
L37A0.510.71
L38A0.030.60
I44V1.000.60
L53A0.030.28
I54V0.160.36
I54A0.050.34
I68V0.860.19
V69A0.080.17
A77G0.860.12
A78G0.780.10
 
src SH3 domain
F10A0.10.080.50
V11A0.030.10
A12G0.050.14
Y16A0.030.34
S18A0.280.22
D23A0.130.34
L24A0.260.38
S25A0.030.29
F26A0.40.35
E30A0.620.25
R31A0.230.21
L32A0.550.32
V35A0.770.65
W42A0.250.62
W43A0.150.61
L44A0.540.77
H46A0.080.61
S47A0.950.45
L48A0.720.53
T50A0.860.47
Q52A0.450.44
T53A0.680.70
Y55A0.560.73
I56A0.710.59
P57A0.240.49
S64A0.140.07
 
barstar
I5V0.630.210.45
Q9G0.720.17
I13A0.450.30
Q18G0.690.48
A25G0.680.66
A36G0.70.69
L37A0.590.74
L41A0.450.76
V45A0.470.68
L49A0.470.53
V50G0.770.37
F56A0.350.32
Q58G0.110.24
Q61G0.090.20
T63A0.380.17
A67G0.30.31
E68A0.520.29
V70A0.410.61
Q72G0.810.60
A77G0.90.74
A79G0.630.68
T85A0.510.54
 
villin14T
L3A0.350.190.43
V7A0.450.26
I18A0.490.66
I20V0.260.66
I23A0.650.81
M28A0.580.65
C44A0.850.79
V46A0.690.88
L47A0.430.79
L48A0.620.78
I61A0.50.86
L65A0.240.80
E73A0.690.70
A77G0.520.77
A78G0.560.76
T81A0.750.80
M84A0.680.65
L114A0.030.50
 
B1 domain of protein L
V4A0.510.430.18
T5A0.260.62
I6A0.370.63
I6V0.530.61
K7A0.620.78
A8G0.530.69
N9A0.120.82
L10A0.430.64
I11A0.720.81
I11V0.180.84
F12A0.20.67
N14A0.850.54
T17A0.40.70
T19A0.210.74
A20G0.350.61
E21A0.750.68
F22A0.410.52
K23A0.470.56
T25A0.430.53
F26G0.260.56
A29G0.230.49
T30A0.080.51
S31G0.110.39
E32G0.110.40
A33G0.250.38
Y34A0.050.35
A35G0.280.34
Y36A0.270.37
A37G0.110.38
L40A0.130.35
N44A0.070.37
T48A0.260.69
V49A0.320.58
V51A0.190.70
Y56A0.150.65
T57A0.130.82
L58A0.270.69
N59A0.170.86
I60A0.170.75
I60V0.220.73
K61A0.160.81
 
TI I27 domain of titin
I2A0.450.17-0.19
V4A0.290.38
L8A0.280.53
V15A0.010.63
A19G0.380.82
I23A0.820.51
L25A0.420.39
V30A0.450.37
L36A0.50.41
L41A0.40.36
C47A0.420.44
I49V0.660.42
H56A0.520.50
L58A0.790.71
L60A0.670.71
C63A0.230.79
M67A0.130.66
V71A0.630.66
A75G0.630.53
A82G0.160.61
L84A0.050.65
V86A0.010.66
 
FNfn10 domain of fibronectin
L8A0.550.40-0.50
A13G0.420.57
V29A0.250.81
Y32A0.470.89
I34A0.610.96
Y36A0.520.90
F48A0.310.95
V50A0.390.96
A57G0.270.89
I59A0.240.84
I59V0.390.86
L62A0.380.64
Y68A0.270.69
Y68F0.510.72
I70A0.330.71
V72A0.510.73
A74G0.650.71
Y92A0.790.20
 
acylphosphatase
Y11F0.930.500.41
V13A0.370.51
V17A0.10.50
V20A0.180.44
A30G0.420.59
V36A0.220.41
V39A0.140.47
T42A0.370.48
V47A0.540.49
V51A0.390.58
P54A0.980.56
M61A0.210.63
P71A0.090.52
I75V0.020.52
T78S0.020.46
I86V00.27
L89A0.070.29
 
Im9
I7V0.150.64-0.05
A13G0.980.86
F15A0.570.80
L16A0.520.65
L18A0.400.90
V19A0.320.74
I22V0.310.93
T27S0.120.95
L33A0.270.95
L36A0.250.95
V37A0.150.87
L52A0.030.70
I53V0.070.80
I67V0.410.52
V68A0.230.58
V71A0.360.47
A76G0.370.35
A77G0.370.36
F83A0.310.37
 
B domain of protein A
A13G0.100.740.58
F14A0.900.88
F14G0.400.85
I17V1.000.89
L18G1.000.95
L20A0.100.76
L20G0.100.78
L23A0.100.64
F31A0.300.87
F31G0.500.88
I32A0.500.97
I32G0.600.97
L35A0.400.79
L35G0.500.81
P39G0.200.48
S40G0.500.54
L45A0.600.79
L45G0.300.79
L46A0.200.73
L46G0.300.73
A49G0.200.69
L52A0.300.59
L52G0.100.59

Experimentally found Φ-values (larger 0.5) and predicted amyloidogenic regions