Laboratory of Protein Physics organized in 1967 and headed till March, 1999 by Prof. O.B.Ptitsyn (1929-1999). O.B.Ptitsyn was the founder of the Russian School of Protein Physics. The following groups branched from the laboratory: a Computer Group, a Group of Stereochemistry of Proteins and Nucleic Acids, and a Group of Physical Investigation of Macromolecules (now the Group of Physics of Nucleoproteins).
Main goals: theoretical and experimental investigation of protein folding, including:
- Theoretical and experimental studies of the main stages of the process of protein folding into the functional 3D structure starting from the completely unfolded polypeptide chain. This includes study of nucleation of all stages of protein folding, study of all protein folding intermediates (both in vitro and in vivo), as well as a study of the functional role of the intermediate states.
- Elaboration of the theory of protein three-dimensional structure and the algorithms for the calculation of the protein 3D structure from its amino acid sequence.
- Study of mobility of protein structures and their changes during the functioning.
- Protein engineering, in particular, the construction, synthesis and study of proteins de novo designed to adopt a given 3D structure.
|142290 Pushchino, Moscow region.|
Institutskaya street, 4,
Institute of Protein Research RAS,
Laboratory of Protein Physics.
|+7 (095) 632-78-71|